Regulatory Class: ℞

Generic Name: Pyrazinamide

Formulations: 250mg/5mL; 500mg/5mL suspension

Indications or Uses: As part of multidrug regimen for all forms of pulmonary & extrapulmonary TB.

Dosage and Directions for Use: Adult & childn 35 mg/kg daily, max daily dose of 3 g or 50 mg/kg 3x a wk or 75 mg/kg twice wkly. Partial intermittent therapy: Administer w/ INH & rifampicin daily for the 1st 2 mth. Afterwards, treatment w/ INH & rifampicin will continue for the next 4 month.

Administration: Taken with food

Contraindication: Liver damage

Special Precaution: Impaired renal function or a history of gout. DM. Pregnancy & lactation.

Adverse Reaction: Liver toxicity. Anorexia, nausea, vomiting, arthralgia, malaise, fever, sideroblastic anemia & dysuria. Rare photosensitivity & skin rashes.

Presentation/Packaging: Oral suspension Z-cure 250 mg/5 mL x 120 mL. Oral suspension Z-cure Forte 500 mg/5 mL x 120 mL.

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