Generic Name: Cefuroxime (tab: axetil; inj: Na)

Formulations:500mg tablet; 750mg IV

Indications or Uses Treatment of infections caused by susceptible organisms eg, bone & joint infections, bronchitis, gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin & soft tissue infections, UTI & for surgical infection prophylaxis.

Dosage and Directions for Use: Zoltax Adult Uncomplicated UTI 125 mg bid. Resp tract infections 250-500 mg bid. Pneumonia or acute exacerbations of chronic bronchitis 1.5 g bid or 750 mg parenteral dose bid followed by 500 mg tab bid. Lyme disease 500 mg bid for 20 days. Uncomplicated gonorrhea Single 1 g oral dose & 1 g probenecid. Zoltax Injection Usual dose: 750 mg to 1.5 g 8 hrly for 5-10 days. Uncomplicated UTI & pneumonia, skin & skin structure infection, disseminated gonococcal infection 750 mg 8 hrly. Severe or complicated infections, bone & joint infections 1.5 g 8 hrly. Bacterial meningitis Dose should not be >3 g 8 hrly. Pre-op prophylaxis 1.5 g dose IV before surgery or at anesth induction (then 12 hrly for a total of 6 g).

Administration: Taken with or without food

Contraindication: Hypersensitivity to cephalosporins

Special Precaution: Renal impairment. Monitor renal function periodically. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn < 6 yr. Elderly ≥65 yr.

Adverse Reaction: Diarrhea, nausea, vomiting, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Interactions: Probenecid, oral estrogen/progesterone contraceptives.

Presentation/Packaging: Zoltax Film coated tablet 500 mg x 48's . Zoltax Injection powd for inj (vial) 750 mg x 1's .

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