Regulatory Class: ℞

Generic Name: Memantine HCl

Formulations: 10mg tablet

Indications or Uses: Alzheimer's disease (moderate to severe w/ or w/o dementia) & Parkinson's disease w/ dementia

Dosage and Directions for Use: 5 mg daily in the morning for the 1st wk, increased wkly at 5-mg increments to a max dose of 20 mg daily. Dose ≥10 mg should be taken in 2 divided doses.

Administration: Taken with or without food

Contraindication: Hypersensitivity

Special Precaution: Close monitoring in patients w/ recent MI, uncompensated CHF & uncontrolled HTN. Patients at risk of convulsions; conditions that increase urinary pH (eg, drastic changes in diet, renal tubular acidosis, severe UTI). Seizures may occur rarely. Renal impairment. Pregnancy & lactation. Childn.

Adverse Reaction: Constipation, dizziness, headache, somnolence. Anxiety, hallucinations, confusion, abnormal gait, hypertonia, vomiting, cystitis, increased libido.

Interactions: May increase incidence & severity of adverse effects w/ amantadine, ketamine or dextromethorphan. Enhanced effects of dopaminergics & antimuscarinics. May reduce actions of barbiturates & antipsychotics. May alter effects of antispasmodics, baclofen & dantrolene. Reduced clearance w/ carbonic anhydrase inhibitors & Na bicarbonate.

Presentation/Packaging: Film coated tablet 10 mg x 100's.

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