Regulatory Class: ℞

Generic Name: Tramadol Hydrochloride

Formulations: Cap-50mg; IM/IV 50mg/mL (100mg/2mL)

Indications or Uses Moderate to severe acute & chronic pain, painful diagnostic procedures & surgery.

Dosage and Directions for Use: Cap Individualized dosage. 50-100 mg every 4-6 hr. Max: 400 mg/day. Inj 50-100 mg IV every 4-6 hr over 2-3 min or by IV infusion. Post-op pain Initially 100 mg followed by 50 mg every 10-20 min if necessary. Max (including initial dose): 250 mg in the 1st hr. Doses are 50-100 mg every 4-6 hr to total daily dose of 600 mg. CrCl < 30 mL/min & severe hepatic impairment Dosage interval should be increased to 12 hr. Max: 200 mg/day.

Administration: Take with or without food

Special Precaution: Renal or liver impairment. Avoid in severe renal impairment. Patients w/ history of epilepsy or those susceptible to seizures. Do not take during light planes of general anesth. May have lower potential for producing dependence than morphine.

Adverse Reaction: Nausea, vomiting, constipation, drowsiness & confusion; tolerance (long-term use). Respiratory depression; hypotension, Hypertension; anaphylaxis, hallucinations.

Interactions: Diminish analgesic activity by reducing serum concentration w/ carbamazepine. Increased risk of seizures w/ other drugs that have potential to lower seizure threshold. Inhibited reuptake of noradrenaline & serotonin. Enhance monoaminergic neurotransmission of lithium, Tricyclic antidepressants (TCAs) & Selective serotonin reuptake inhibitors (SSRIs). Inj: Incompatible w/ inj of diazepam, diclofenac Na, indomethacin, midazolam & piroxicam.

Presentation/Packaging: Cap 50 mg x 50's. Inj (amp) 50 mg/mL x 2 mL x 10's.

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