Generic Name:  Pregabalin + Methylcobalamin

Regulatory Class: Rx

Formulations: Pregabalin 75 mg, Methylcobalamin 750 mcg

Indications or Uses: Management of neuropathic pain associated w/ peripheral neuropathy; neuralgia; fibromyalgia. Adjunct therapy for adult patient w/ partial onset seizures.

Dosage or Directions for use:  Initially 1 cap bid. Patient previously on gabapentin should have wash-out period of 1 wk prior to initiation of pregabalin.

Administration: take w/ or w/o food. 

Contraindications: Hypersensitivity.

Special Precautions: Discontinue immediately if swelling of the face, mouth (tongue, lips, & gums), & neck (throat & larynx); if myopathy is diagnosed or suspected or if markedly elevated creatinine kinase levels occur. Should not be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. W/drawal symptoms. Suicidal behaviour & ideation; peripheral edema; encephalopathy. Weight gain; blurred vision; decreased platelet count; PR interval prolongation may occur. Patients w/ CHF NYHA class III or IV; history of drug abuse. Concomitant use w/ drugs potential to produce constipation eg, opioid analgesics. May cause dizziness & somnolence & impair ability to drive or operate machinery. Pregnancy & lactation.

Adverse Reaction: Pregabalin: Dizziness, somnolence, headache, ataxia, asthenia, dry mouth, constipation, edema, blurred vision, weight gain, & difficulty with concentration/attention).

Interactions: Reduced absorption of vit B12 from the GIT w/ neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole & colchicine. Serum concentration may be decreased with the use of oral contraceptives. Parenteral chloramphenicol may attenuate the effect of vit B12 in anemia. May experience additive CNS side effects w/ opiates or benzodiazepines. May potentiate impairment of motor skills & sedating effects of alcohol. Methylcobalamin: May alter intestinal microflora & decrease the absorption of w/ antibiotics; metformin, para-aminosalicyclic acid & KCl. May decrease enterohepatic re-absorption w/ cholestyramine, colchicine or colestipol. Produce functional deficiency w/ nitrous oxide.

Presentation or Packaging:  Capsule 75mg/70mcg x 30's

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