Regulatory Class: ℞

Generic Name: Metformin HCl

Formulations: 500mg tablet

Indications or Uses As monotherapy or in combination w/ a sulfonylurea in Non-Insulin-Dependent Diabetes Mellitus (NIDDM) not responding to dietary modification. Adjuvant in type 1 diabetics or insulin deficient patients who are not adequately controlled w/ insulin.

Dosage and Directions for Use: Initially 500 mg three times a day. Dose may be gradually increased to max 3 g daily.

Administration: Take with food

Contraindication: Renal impairment, liver or heart failure, recent MI, dehydration, alcoholism & other conditions predisposing to lactic acidosis

Special Precaution: Not recommended during pregnancy & lactation

Adverse Reaction: Anorexia, nausea, diarrhea, metallic taste, wt loss. Impaired vit B12 absorption. Rarely, lactic acidosis

Interactions: Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, vancomycin, trimethoprim. May increase levels w/ cimetidine

Presentation/Packaging: Film Coated tablet 500 mg x 60's.

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